Here goeas a random unsubstantiated hypothesis. CDPR/FT are already taking a huge liberty with the original by turning the remake into open world. What if they take more liberties in the narrative department? What would be the prime candidates for changes?
First and foremost I'd say Geralt's memory loss no longer makes sense in a remake that's released nearly 20 years after the original game (assuming the remake ships in 2025 or around that time). There is no mystery any more, to motivate the player to discover the things Geralt has forgotten.
Additionally, if you remove the memory loss as a precondition for his relationships with the main cast, this opens up the opportunity to rewrite much of his relationships with Zoltan, Triss, Shani, introduce Yennefer into the plot. Possibly even introduce Ciri and adapt or rewrite the Alvin questline.
I'm not considering this too implausible mainly because CDPR reps have said themselves that in Witcher 1 they resorted to the memory loss because the backstory was too much for them to handle in one game and they lacked the experience to do it justice.
Just a speculation, but "wouldn't it be cool if..."