Time is what matters, not the numbers involved.
That depends on your conception of what a 'Hitpoint' mean. And most conflate that with 'Health'.
It makes sense that a High Magic setting has these superhuman fighters who can withstand stronger blows and dodge a lot (AC). There, it also makes sense that their bodies are more resistant than what you'd expect (HP). And wether one or the other value is used to assert the enemies' power and (supposed) superiority over the player is a key difference of wether the world itself makes sense.
In the IE games, most enemies are as vulnerable as your characters. Indeed, both sides are quite vulnerable once you manage to hit the fighters and bring the enemies' defenses down. So while you may spen two whole rounds of 6 seconds dispelling the enemies' defenses or disabling their AC somehow, the fight's end is abrupt. It makes sense that the evil wizard, once his Stoneskin or whatever is dispelled, would actually suffer strikes of multiple fighters overwhelming him.
In DA:O, if you conflate Hitpoints with Health, then enemies are often strangely more powerful than you in a single way. Becoming a wonder why your character is the legendary hero. After all, its not just Grimdark Abominations and Dragons who have a stronger body than yours. Some nobody who happened to be flagged as a 'Lieutenant' enemy also does. That same wizard, let's call him Zathrian, doesn't need spell defenses since multiple strikes to his face won't dent his Health.