The game takes place in a post-apocalyptic New York called "Neo New York", after a "chaos dunk" causes the death of millions.
Twelve years prior to the game, Charles Barkley, in an attempt to impress his son Hoopz Barkley, performs a Chaos Dunk -- and inadvertently kills almost everyone present. As a result, basketball was made illegal and nearly all great players were killed in "The Great B-Ball Purge of 2041" (a.k.a "B-Ballnacht")[2].
In 2053, another Chaos Dunk rocks Manhattan, killing fifteen million, and the blame falls on Charles, who is believed to be the only human capable of performing the Chaos Dunk.[2][4] With the help of the Ultimate Hellbane, Charles escapes his pursuers: the B-Ball Removal Department, led by ex-NBA all-star Michael Jordan. Charles follows Ultimate Hellbane through the B-Ball Catacombs to the tomb of Lebron James, discovering that the Ultimate Hellbane is actually Balthios - the Octoroon great grandson of Lebron James. James contacts Charles from the B-ball dimension, offering him a warning which tells him to "seek the Cyberdwarf."