How about an RPG where you start out as a wimpy first-grade kid in a tough inner city public school?
The goal of the game would be to graduate from high school and there would be different endings depending on the reputation you have established, grade point average and honors, chicks banged, etc. However, your character ages at an automatic pace and you must graduate before you reach your 21st birthday, or else you get the "bad" ending where everyone realizes you're a retard and a failure at life.
Gameplay would consist of fighting other kids (to protect your honor, increase your infamy or coerce them to do as you say), leveling up your skills (such as sweet-talking, brawling, and cheating), having sex with the prettiest/most popular girls (while avoiding getting them pregnant), and doing whatever is necessary to succeed academically. You can get money by working at some crappy job, mugging/stealing from other kids, or skillfully convincing your parents to give you an allowance. With it, you can buy things such as weapons, charisma-boosting or intimidating clothing, drugs (from coke to Ritalin), cheating aids, and other items/services to help you in your quest.
By pumping charisma, you can get more kids to ally with you and eventually form your own gang. Higher charisma also means they will remain loyal to you in case your reputation gets knocked down. You can also pay other kids to help you out in certain situations like backing you up in fights (as long as they think they have a chance at winning) or doing your homework; however, you must be careful to find out what's your standing with them before you hire them, or else they might end up betraying you instead of providing the service you asked for.
You can choose to play a "good" character who succeeds through honest work, while trying to avoid violence and screwing girls with their full consent; or you can play an "evil" character who usually takes the shorter and "smarter" paths to success, recognizes the need to use violence as a political tool, and is not above using drugs or "strong arm" tactics to have his way with girls. Of course, you don't want to shift your karma one way or the other too much, lest you risk drawing unwanted attention from the more powerful members of your opposing factions at school.
So there you have a blueprint for a successful RPG, start making it.
Edit: Of course, you should also be able to choose your race at the beginning of the game, and this would have a significant effect on your stats. Black kids would get a bonus to Strength and Endurance but a penalty to Intelligence and Perception, Asians +INT +LUK -CHA -AGI, Latinos +CHA +AGI -INT -LUK, Jews +INT +CHA -STR -END, and of course Whites would be all-rounders without any bonuses or penalties.