Kem0sabe
Arcane
"None of them are worth it", not true, just look at the people on the Wasteland 2 forums who actually know what they're talking about, some are greatly useful, but what's more important is that many change the way you play, which you complain about the perks not doing.
Opportunist, Two pump chump, and Brittle Bones are good quirks that can change how you use your characters.
The most dramatically different character I've built however was with Raised in the Circus, blades, leadership, charisma, luck, and speed. Made me a knife wielding butcher Clown with crazy high evasion and the taunt ability, which lowers the CtH of anyone he's near, pretty fun thematic build, dodging bullets like Jim Carry in The Mask, then gutting them with lucky criticals.
I think D:OS is better than PoE, personally.
Worth it in the sense that the combat is such a banal, boring, easy affair that with or without perks you will steam roll through every encounter.