Gemini Rue
The game is a real mindfuck. Literally the only game which ever managed to stun me. And one of the very few games which managed to have a serious emotional impact on me. And it is just damn good.
I can almost promise that you will love this game if you loved the Blade Runner movies. But no, it is not about synths, it wouldn't be unique in that case. It does ask the question what it means to be human though, but in a completely new / unique way.
Seriously, just play it, it is one of the best games ever made.
The Entire Blackwell Series
Great adventure games. The premise is unusual but not really unique: You have to help the ghosts of dead people to find peace. One unique thing about the series is that it mostly deals with real world problems real world people have e.g. you don't have to rescue your girlfriend from a ghost pirate or something like that. Instead you get e.g.; Why did this college girl overdose on drugs? And no, there is no supernatural reason, it is all real life shit that happens every day to ordinary people. And another thing which makes these games unique is that they deal with such topics in a very mature way. I would say the Blackwell games are the most "grown-up" games I have ever played. They are heartbreakingly sad and tragic though. Again, you are always dealing with the ghosts of dead people who can't find peace - and there are reasons why these souls can't find peace and accept death. Usually very sad and tragic ones. And yes, to point that out again, your "job" in these games is to make people accept death. I can almost promise you will like these games if you are the melancholic / depressive type.
Cloudpunk
This one is hard to describe. Technically one could say this is a voxel cyberpunk version of Euro Truck Simulator
The appeal of the game is also hard to explain. Objectively speaking there isn't much real gameplay but the game is extremely immersive somehow.
I can almost promise that if you like cyberpunk you will like this game because it is honestly the most immersive cyperpunk game I have ever played.
The immersion is unfortunately brutally broken multiple times by very forced scenes of American far-left preaching. Like they added characters to the game just to diss Joe Rogan and Ben Shapiro, and as you might imagine those characters stick out like sore thumbs in the otherwise very well made cyberpunk world. The main character also occasionally makes those self-righteous "I am so smart and noble and those people are all so stupid and evil." comments far-left types are infamous for.
But then, that shit is like 5% of the game and the rest is so good that I still recommend it despite of those aspects.
I mean I always thought those people who refuse to read H.P. Lovecraft because there is a "bigoted" line here and there are morons with mental issues. We basically have the same situation here, just here the question is if you can look past occasional elements of American far-left derangement.