The first time I play 113 I innocently turn on Drop All. Restart pretty damn quick. I know it's more realistic than a vapoured loots but man, talk about a jade experience. When you see each target you no longer contemplate what goodies you might get from that walking corpse. You get in , you massacre them quick, then check the sector inventory. Talk about boring.
The fun thing to play is boxing then stealing each and every one of them. It require me to set up ambush, force me to use dangerous but loud weapons as a last resort, and it make my palm sweat to guess which loots shall I have. Time consuming, but oh so fun.
of course, for 1st timer it could be quite dangerous and frustrating as you dont know all the tricks of trade. So in that case, you could play what style you want:
Easiest way : play night fighting, use night ops, kill them all with silenced weapons.
Middle way: Daytime assault, frontal attack. It has its moments, and sometimes when I feel like finish a sector quick I do this shit. Very fun in its own brutal way.
Hard way: take it easy, take it slow. stealing shits, maintain gunrunning to Bobby Ray, fighting for money in San Mona. Since you play slow, when you get down to the South, enemies are elites with top of the line equipments. And the patrol attacks are simply dangerous. In late game, even with your full roster you cant deal with all the attack, since you cant be everywhere. And in that case, withdraw then recapture is sometimes easier than stand and fight.
Mind you, to each his own. If you want to play Drop All or whatever, that is your right, I wont squeak a pip. But if you are talking shit about my way, be prepared to be argued down.