QTEs. Fuck you, Witcher 2, I know it's ACTION RPG, but you went too far.
Lack of challenge. Basically when no matter how much you fuck up you still faceroll 90% of content, when you have to heavily handicap yourself and/or use mods to have any challenge at all (hi, New Vegas). Same goes for quest markers for everything (find the missing plot device! Well, here it is, my map has already found it), or really whenever the game assumes the player is a retard.
Level-scaling. Combines the best of "our audience is retards" and "we can't create challenging content for shit".
WoW-like cartoonish graphics and that kind of aesthetics in general (giant, retarded looking pauldrons and helmets, everything with 10 different fire/ice/magic particle effects that obscure the view). It's just a way to hide that your graphics suck, nobody goes with this shit because they think it will look good.
Pseudo-retro graphics (it's just like 8-bit platformers!). Ok, maybe I don't automatically hate those, but if that's how you advertise your game you'll have a hard time convincing me to buy it. 2D platformers can be made with modern technology, you lazy fucks.
"We want to reach a broader audience, so we changed/simplified that thing the audience we already have liked". Strawman, I know, but can anyone name a game when they said something like that and the game didn't suck?
Zombies? Nothing against zombies (as in, this game contains zombies), but if your game is a "zombie game", I'll pass.